Quantitative magnetic resonance imaging (qMRI) goes beyond conventional MRI, which
aims primarily at local image contrast. It provides specific physical parameters related to the …

Recent years have seen an increased understanding of the importance of myelination in
healthy brain function and neuropsychiatric diseases. Non-invasive microstructural magnetic …

Objectives Currently, multiple sclerosis is treated with anti-inflammatory therapies, but these
treatments lack efficacy in progressive disease. New treatment strategies aim to repair …

Neuroaxonal pathology is a main determinant of disease progression in multiple sclerosis;
however, its underlying pathophysiological mechanisms, including its link to inflammatory …

Quantitative susceptibility mapping (QSM) and effective transverse relaxation rate (R2*)
mapping are both highly sensitive to variations in brain iron content. Clinical Magnetic …

The neocortex of the human brain is the seat of higher brain function. Modern imaging
techniques, chief among them magnetic resonance imaging (MRI), allow non-invasive …

Magnetization transfer contrast has yielded insight into brain tissue microstructure changes
across the lifespan and in a range of disorders. This progress has been aided by the …

The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a
myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for …

T1-weighted divided by T2-weighted (T1w/T2w) myelin maps were initially developed for
neuroanatomical analyses such as identifying cortical areas, but they are increasingly used …

The knowledge of relaxation times is essential for understanding the biophysical
mechanisms underlying contrast in magnetic resonance imaging. Quantitative experiments …