Sedentary behavior and physical inactivity are among the leading modifiable risk factors
worldwide for cardiovascular disease and all-cause mortality. The promotion of physical …

The European Society of Cardiology (ESC) has published a series of guidelines on heart
failure (HF) over the last 25 years, most recently in 2016. Given the amount of new …

Making a firm diagnosis of chronic heart failure with preserved ejection fraction (HFpEF)
remains a challenge. We recommend a new stepwise diagnostic process, the 'HFA–PEFF …

Background: Chronic kidney disease and type 2 diabetes are independently associated with
heart failure (HF), a leading cause of morbidity and mortality. In the FIDELIO-DKD …

Background: Poor health-related quality of life (HRQL) is common in heart failure (HF), but
there are few data on HRQL in HF and the association between HRQL and mortality outside …

Background Chronotropic incompetence has shown to be associated with a decrease in
exercise capacity in heart failure with preserved ejection fraction (HFpEF), yet β-blockers are …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Aims We tested the hypothesis that candesartan improves outcomes in heart failure (HF)
with mid‐range ejection fraction [HFmrEF; ejection fraction (EF) 40–49%]. Methods and …

Cardiac rehabilitation is a complex intervention that seeks to improve the functional capacity,
wellbeing and health-related quality of life of patients with heart disease. A substantive …

Iron deficiency is an extremely common comorbidity in patients with heart failure, affecting
up to 50% of all ambulatory patients. It is associated with reduced exercise capacity and …