Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …

Although mast cells were discovered more than a century ago, their functions beyond their
role in allergic responses remained elusive until recently. However, there is a growing …

Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
Journal of Respiratory and Critical Care Medicine ATS Journals Logo Official Publications …

Oxidation products of low-density lipoproteins have been suggested to promote
inflammation during atherogenesis, and reticulocyte-type 15-lipoxygenase has been …

Agonist-induced release of endothelial cell specific storage granules, designated Weibel-
Palade bodies (WPBs), provides the endothelium with the ability to rapidly respond to …

Over recent decades, various studies have argued that the metastatic tissue
microenvironment is fully controlled by the intrinsic properties of the cancer cells (growth …

Mast cells (MCs) promote a wide range of localized and systemic inflammatory responses.
Their involvement in immediate as well as chronic inflammatory reactions at both local and …

The presence of activated platelets and platelet-leukocyte aggregates in the circulation
accompanies major surgical procedures and occurs in several chronic diseases. Recent …

Lipid-derived mediators play critical roles in inflammation and other multicellular vascular
processes, including atherosclerosis and thrombosis (1). The lipoxins (LXs) were first …

Acute coronary syndrome (ACS) is a set of signs and symptoms caused by a reduction of
coronary blood flow with subsequent myocardial ischemia. ACS is associated with activation …