The free-radical gas nitric oxide (NO) plays an important role in a diverse range of
physiological processes. It is synthesized from the precursor l-arginine by the enzyme NO …

Alcohol dependence remains among the most common substance abuse problems
worldwide, and compulsive alcohol consumption is a significant public health concern …

Abstract Cytochrome P450 (CYP) 2D6 is expressed in liver, brain and other extrahepatic
tissues where it metabolizes a range of centrally acting drugs and toxins. As ethanol can …

Caenorhabditis elegans senses multiple environmental stimuli through sensory systems and
rapidly changes its behaviors for survival. With a simple and well‐characterized nervous …

Effects of agmatine, which is an endogenous polyamine metabolite formed by
decarboxylation of l-arginine, have been investigated on the ethanol withdrawal syndrome …

Aims: Despite substantial preclinical evidence that supports the involvement of
noradrenergic (NA) and serotonergic (5-HT) mechanisms in alcohol withdrawal, human data …

BACKGROUND: New medications for alcohol use disorder (AUD) are needed. Long-term
alcohol consumption leads to a dysregulated dopamine system. A novel approach to …

Alcohol addiction is a debilitating disorder producing maladaptive changes in the brain,
leading drinkers to become more sensitive to stress and anxiety. These changes are key …

Depression and use of addictive substances are two of the most frequent public health
problems of adolescents. However, little is known about the association between depression …

This review discusses recent research of mood disorders associated with the cessation of
psychoactive substances, with an emphasis on preclinical studies that have been published …