Systemic sclerosis, commonly known as scleroderma, is an autoimmune disorder
characterized by vascular abnormalities, autoimmunity, and multiorgan fibrosis. The exact …

Chemokines, a family of small secreted chemotactic cytokines, and their G protein-coupled
seven transmembrane spanning receptors control the migratory patterns, positioning and …

Objective Skin inflammation and photosensitivity are common in patients with cutaneous
lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), yet little is known …

Objective Systemic sclerosis (SSc) features multiorgan fibrosis orchestrated predominantly
by activated myofibroblasts. Endothelial-to-mesenchymal transition (EndoMT) is a …

Scleroderma (SSc) is a complex disease that involves activation of the immune system,
vascular complications, and tissue fibrosis. The histone methyltransferase enhancer of zeste …

Chemokines were originally defined as cytokines that affect the movement of immune cells.
In recent years, due to the increasing importance of immune cells in the tumor …

Objective Intravenous iloprost improves Raynaud's phenomenon (RP) and promotes
healing of digital ulcers in systemic sclerosis (SSc; scleroderma). Despite a short half‐life, its …

Objective Vascular dysfunction represents a disease‐initiating event in systemic sclerosis
(SSc; scleroderma). Results of recent studies suggest that epigenetic dysregulation impairs …

Systemic sclerosis is a chronic autoimmune connective tissue disease characterized by
vascular injury and fibrosis and by an impaired angiogenesis which cannot ensure an …

Systemic sclerosis is a rare acquired systemic disease characterised by heterogeneous
evolution and outcome. Each year novel insights into the pathogenesis, diagnosis and …