In this Review, we describe the singular success of attractor neural network models in
describing how the brain maintains persistent activity states for working memory, corrects …

The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

The medial entorhinal cortex is part of a neural system for mapping the position of an
individual within a physical environment. Grid cells, a key component of this system, fire in a …

The hippocampus is crucial for spatial navigation and episodic memory formation.
Hippocampal place cells exhibit spatially selective activity within an environment and have …

Cortical networks are composed of glutamatergic excitatory projection neurons and local
GABAergic inhibitory interneurons that gate signal flow and sculpt network dynamics …

Since the first place cell was recorded and the cognitive-map theory was subsequently
formulated, investigation of spatial representation in the hippocampal formation has evolved …

An organism's survival can depend on its ability to recall and navigate to spatial locations
associated with rewards, such as food or a home. Accumulating research has revealed that …

Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a
hexagonal pattern. When animals move, activity is translated between grid cells in …

Background Neuronal networks in the brain include glutamatergic principal neurons and
GABAergic interneurons (GABA, γ-aminobutyric acid). The latter may be a minority cell type …

The entorhinal cortex (EC) is the major input and output structure of the hippocampal
formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes …