The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19)
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …

Recent advances in the generation, purification and cellular delivery of RNA have enabled
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …

mRNA has broad potential as a therapeutic. Current clinical efforts are focused on
vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical …

The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …

Therapeutic RNA molecules possess high potential for treating medical conditions if they
can successfully reach the target cell upon administration. However, unmodified RNA …

Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …

Current nucleoside-modified RNA lipid nanoparticle (modmRNA-LNP) technology has
successfully paved the way for the highest clinical efficacy data from next-generation …

The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its
unique features compared to plasmid DNA: Transient expression, no need to enter into the …

Atherosclerosis is the main underlying pathology for many cardiovascular diseases (CVDs),
which are the leading cause of death globally and represent a serious health crisis …

Chemically modified mRNA is an efficient, biocompatible modality for therapeutic protein
expression. We report a first-time-in-human study of this modality, aiming to evaluate safety …