Why is manganese so valuable to bacterial pathogens?

J Čapek, B Večerek - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
Apart from oxygenic photosynthesis, the extent of manganese utilization in bacteria varies
from species to species and also appears to depend on external conditions. This …

Structure of a ribonucleotide reductase R2 protein radical

H Lebrette, V Srinivas, J John, O Aurelius, R Kumar… - Science, 2023 - science.org
Aerobic ribonucleotide reductases (RNRs) initiate synthesis of DNA building blocks by
generating a free radical within the R2 subunit; the radical is subsequently shuttled to the …

[HTML][HTML] Structural biology in the age of X-ray free-electron lasers and exascale computing

S Mous, F Poitevin, MS Hunter, DN Asthagiri… - Current Opinion in …, 2024 - Elsevier
Serial femtosecond X-ray crystallography has emerged as a powerful method for
investigating biomolecular structure and dynamics. With the new generation of X-ray free …

Manganese uptake by MtsABC contributes to the pathogenesis of human pathogen group A streptococcus by resisting host nutritional immune defenses

N Makthal, S Saha, E Huang, J John… - Infection and …, 2024 - Am Soc Microbiol
The interplay between host nutritional immune mechanisms and bacterial nutrient uptake
systems has a major impact on the disease outcome. The host immune factor calprotectin …

Room temperature crystallography and X-ray spectroscopy of metalloenzymes

H Makita, M Zhang, J Yano, J Kern - Methods in enzymology, 2023 - Elsevier
The ultrashort (10s of femtoseconds) X-ray pulses generated by X-ray free electron lasers
enable the measurement of X-ray diffraction and spectroscopic data from radiation-sensitive …

[HTML][HTML] Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria

LR Yadav, V Sharma, M Shanmugam… - Current Research in …, 2024 - Elsevier
Class I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside
diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical …

Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases

LR Yadav, SC Mande - bioRxiv, 2023 - biorxiv.org
Class I ribonucleotide reductases consisting of R1 and R2 subunits convert ribonucleoside
diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical …

Why is manganese so valuable to bacterial pathogens?

J Cˇapek, B Vecˇerek - 2023 - europepmc.org
Apart from oxygenic photosynthesis, the extent of manganese utilization in bacteria varies
from species to species and also appears to depend on external conditions. This …

[PDF][PDF] Structural Biology in the age of X-ray Free Electron Lasers and Exascale Computing Sandra Mous, Frédéric Poitevin, Mark S. Hunter, Dilipkumar N. Asthagiri

TL Beck - newswise.com
Serial femtosecond X-ray crystallography has emerged as a powerful method for
investigating biomolecular structure and dynamics. With the new generation of X-ray free …