Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify
preclinical individuals and target potentially disease-modifying therapies towards them …

The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

Spatial navigation is emerging as a critical factor in identifying preclinical Alzheimer's
disease (AD). However, the impact of interindividual navigation ability and demographic risk …

The entorhinal cortex is one of the first regions to exhibit neurodegeneration in Alzheimer's
disease, and as such identification of entorhinal cortex dysfunction may aid detection of the …

Background: Immersive virtual reality (iVR) allows seamless interaction with simulated
environments and is becoming an established tool in clinical research. It is unclear whether …

Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation.
Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of …

A progressive loss of navigational abilities in old age has been observed in numerous
studies, but we have only limited understanding of the neural mechanisms underlying this …

Path integration (PI) is impaired early in Alzheimer's disease (AD) but reflects multiple sub-
processes that may be differentially sensitive to AD. To characterize these sub-processes …

In this review we discuss converging evidence from human and rodent research
demonstrating how path integration (PI) is impaired in healthy aging and Alzheimer's …

Path integration is a spatial navigation ability that requires the integration of information
derived from self-motion cues and stable landmarks, when available, to return to a previous …