A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …

Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

Human immunodeficiency virus (HIV) has a small genome and therefore relies heavily on
the host cellular machinery to replicate. Identifying which host proteins and complexes come …

Endocytic sorting of signalling receptors between recycling and degradative pathways is a
key cellular process controlling the surface complement of receptors and, accordingly, the …

Restriction factors, such as the retroviral complementary DNA deaminase APOBEC3G, are
cellular proteins that dominantly block virus replication,,. The AIDS virus, human …

Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells,
enabling viral RNA replication and counteracting host antiviral responses. Here, we …

By determining protein-protein interactions in normal, diseased and infected cells, we can
improve our understanding of cellular systems and their reaction to various perturbations. In …

Mapping host-pathogen interactions has proven instrumental for understanding how viruses
manipulate host machinery and how numerous cellular processes are regulated. DNA …

Despite the considerable progress in disease gene discovery, we are far from uncovering
the underlying cellular mechanisms of diseases since complex traits, even many Mendelian …

Protein-protein interactions (PPIs) and multi-protein complexes perform central roles in the
cellular systems of all living organisms. In humans, disruptions of the normal patterns of PPIs …