Ischemic heart injury causes death of cardiomyocyte (CM), formation of a fibrotic scar, and
often adverse cardiac remodeling, resulting in chronic heart failure. Therapeutic …

Highlights•Innovations improve induced cardiomyocyte reprogramming efficiency and
maturation.•Optimized strategies induce cardiomyocyte proliferation and cardiac progenitor …

Illuminating the precise stepwise genetic programs directing cardiac development provides
insights into the mechanisms of congenital heart disease and strategies for cardiac …

The manipulation of cell identity by reprograming holds immense potential in regenerative
medicine, but is often limited by the inefficient acquisition of fully functional cells. This …

In the era of personalized cancer treatment, understanding the complexities of tumor biology
and immune modulation is paramount. This comprehensive analysis delves into the …

Spinal cord injury (SCI) is a medical condition affecting~ 2.5–4 million people worldwide.
The conventional therapy for SCI fails to restore the lost spinal cord functions; thus, novel …

In recent years, there have been notable advancements in the ability to programme human
cell identity, enabling us to design and manipulate cell function in a Petri dish. However …

Background Studies have shown that DNA methylation of the CACNA1C gene is involved in
the pathogenesis of various diseases and the mechanism of drug action. However, its …

Fasting-mimicking diet (FMD) can effectively inhibit the viability of breast cancer stem cells
(CSCs). However, the molecular mechanisms underlying the inhibitory function of FMD on …

Cell-cell communication across multiple cell types and tissues strictly governs the proper
functioning of metazoans and extensively relies on interactions between secreted ligands …