NAFLD: mechanisms, treatments, and biomarkers

F Nassir - Biomolecules, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver
disease (MAFLD), is one of the most common causes of liver diseases worldwide. NAFLD is …

Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

P Rada, Á González-Rodríguez, C García-Monzón… - Cell death & …, 2020 - nature.com
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic …

CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis

P Yang, H Qin, Y Li, A Xiao, E Zheng, H Zeng… - Nature …, 2022 - nature.com
Liver metastasis is highly aggressive and treatment-refractory, partly due to macrophage-
mediated immune suppression. Understanding the mechanisms leading to functional …

Role of insulin resistance in MAFLD

Y Sakurai, N Kubota, T Yamauchi… - International journal of …, 2021 - mdpi.com
Many studies have reported that metabolic dysfunction is closely involved in the complex
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …

Pathological implication of protein post-translational modifications in cancer

S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

[HTML][HTML] CD36 tango in cancer: signaling pathways and functions

J Wang, Y Li - Theranostics, 2019 - ncbi.nlm.nih.gov
CD36, a scavenger receptor expressed in multiple cell types, mediates lipid uptake,
immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a …

[HTML][HTML] CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing

H Zeng, H Qin, M Liao, E Zheng, X Luo, A Xiao, Y Li… - Molecular …, 2022 - Elsevier
Objective Enhanced de novo lipogenesis (DNL) in hepatocytes is a major contributor to
nonalcoholic fatty liver disease (NAFLD). Fatty acid translocase (FAT/CD36) is involved in …

CD36 favours fat sensing and transport to govern lipid metabolism

Y Li, X Huang, G Yang, K Xu, Y Yin, G Brecchia… - Progress in lipid …, 2022 - Elsevier
CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a
critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 …

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis

X Luo, E Zheng, L Wei, H Zeng, H Qin, X Zhang… - Cell death & …, 2021 - nature.com
Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in
hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 is associated with both …

An overview of lipid metabolism and nonalcoholic fatty liver disease

K Pei, T Gui, D Kan, H Feng, Y Jin… - BioMed Research …, 2020 - Wiley Online Library
The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major
abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or …