Membrane protein structure and dynamics from NMR spectroscopy

M Hong, Y Zhang, F Hu - Annual review of physical chemistry, 2012 - annualreviews.org
We review the current state of membrane protein structure determination using solid-state
nuclear magnetic resonance (NMR) spectroscopy. Multidimensional magic-angle-spinning …

HIV gp41–mediated membrane fusion occurs at edges of cholesterol-rich lipid domains

ST Yang, V Kiessling, JA Simmons, JM White… - Nature chemical …, 2015 - nature.com
Lipid rafts in plasma membranes have emerged as possible platforms for the entry of HIV
and other viruses into cells. However, little is known about how lipid phase heterogeneity …

Fusion activity of HIV gp41 fusion domain is related to its secondary structure and depth of membrane insertion in a cholesterol-dependent fashion

AL Lai, AE Moorthy, Y Li, LK Tamm - Journal of molecular biology, 2012 - Elsevier
The human immunodeficiency virus (HIV) gp41 fusion domain plays a critical role in
membrane fusion during viral entry. A thorough understanding of the relationship between …

[HTML][HTML] Mapping out the intricate relationship of the HIV envelope protein and the membrane environment

YA Klug, E Rotem, R Schwarzer, Y Shai - Biochimica et Biophysica Acta …, 2017 - Elsevier
The HIV gp160 envelope fusion protein is situated in the viral membrane and mediates virus
entry into its host cell. Increasing evidence suggests that virtually all parts of the HIV …

A strong correlation between fusogenicity and membrane insertion depth of the HIV fusion peptide

W Qiang, Y Sun, DP Weliky - Proceedings of the National …, 2009 - National Acad Sciences
Fusion between the membrane of HIV and the membrane of a host cell is a crucial step in
HIV infection and is catalyzed by the binding of the fusion peptide domain (HFP) of the HIV …

HIV fusion peptide penetrates, disorders, and softens T-cell membrane mimics

S Tristram-Nagle, R Chan, E Kooijman… - Journal of molecular …, 2010 - Elsevier
This work investigates the interaction of N-terminal gp41 fusion peptide (FP) of human
immunodeficiency virus type 1 (HIV-1) with model membranes in order to elucidate how FP …

Membrane cholesterol regulates the oligomerization and fusogenicity of SARS-CoV fusion peptide: implications in viral entry

G Meher, S Bhattacharjya… - Physical Chemistry …, 2023 - pubs.rsc.org
N-terminal residues (770–788) of the S2 glycoprotein of severe acute respiratory syndrome
coronavirus (SARS-CoV) have been recognized as a potential fusion peptide that can be …

Very broad distribution of β sheet registries of the HIV gp41 fusion peptide supports mutational robustness for fusion and infection

Y Zhang, SD Schmick, L Xie, U Ghosh… - Proceedings of the …, 2024 - pnas.org
HIV, like other membrane-enveloped viruses, has protein spikes that include a fusion
peptide (Fp) segment that binds the host cell membrane and plays a critical role in fusion …

The cytoplasmic domain of the SARS-CoV-2 envelope protein assembles into a β-sheet bundle in lipid bilayers

AJ Dregni, MJ McKay, W Surya… - Journal of Molecular …, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) envelope (E) protein
forms a pentameric ion channel in the lipid membrane of the endoplasmic reticulum Golgi …

Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating

PS Aguilar, MG Heiman, TC Walther… - Proceedings of the …, 2010 - National Acad Sciences
Under mating conditions, yeast cells adopt a characteristic pear-shaped morphology, called
a “shmoo,” as they project a cell extension toward their mating partners. Mating partners …