Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

Summary Background The TARGIT-A trial compared risk-adapted radiotherapy using single-
dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam …

Purpose To analyse the clinical outcome after salvage lumpectomy and multi-catheter
brachytherapy (MCB) for ipsilateral breast tumour recurrence (IBTR). Material and methods …

BACKGROUND Based on our laboratory work and clinical trials we hypothesised that
radiotherapy after lumpectomy for breast cancer could be restricted to the tumour bed. In …

Radiotherapy plays an important part in the management of breast cancer. Especially after
breast-conserving surgery, external whole breast irradiation, occasionally with an additional …

Purpose To evaluate the clinical outcomes of a very-accelerated partial breast irradiation
(vAPBI) in the elderly based on a single fraction of multicatheter interstitial high-dose rate …

A joint analysis of clinical data from centres within the European section of the International
Society of Intraoperative Radiation Therapy (ISIORT-Europe) was undertaken in order to …

Background To update the clinical outcome of an elderly women cohort with early breast
cancer who underwent accelerated partial breast irradiation (APBI) based on a post …

Objective To evaluate clinical outcome after accelerated partial breast irradiation (APBI) in
the elderly after high-dose-rate interstitial multi-catheter brachytherapy (HIBT). Methods and …

Purpose Breast cancer in the elderly has become a public health concern; there is a need to
re-design its treatment with a view to de-escalation. Our paper sets out the rationale for a …