In vivo functional screening for systems-level integrative cancer genomics
With the genetic portraits of all major human malignancies now available, we next face the
challenge of characterizing the function of mutated genes, their downstream targets …
challenge of characterizing the function of mutated genes, their downstream targets …
Transposons as tools for functional genomics in vertebrate models
Genetic tools and mutagenesis strategies based on transposable elements are currently
under development with a vision to link primary DNA sequence information to gene …
under development with a vision to link primary DNA sequence information to gene …
Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping
Despite developments in targeted gene sequencing and whole-genome analysis
techniques, the robust detection of all genetic variation, including structural variants, in and …
techniques, the robust detection of all genetic variation, including structural variants, in and …
Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing–based approach
Integration of the viral DNA into host chromosomes was found in most of the hepatitis B virus
(HBV)–related hepatocellular carcinomas (HCCs). Here we devised a massive anchored …
(HBV)–related hepatocellular carcinomas (HCCs). Here we devised a massive anchored …
Whole Genome Resequencing Reveals Natural Target Site Preferences of Transposable Elements in Drosophila melanogaster
RS Linheiro, CM Bergman - PloS one, 2012 - journals.plos.org
Transposable elements are mobile DNA sequences that integrate into host genomes using
diverse mechanisms with varying degrees of target site specificity. While the target site …
diverse mechanisms with varying degrees of target site specificity. While the target site …
Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma
SM Kas, JR De Ruiter, K Schipper, S Annunziato… - Nature …, 2017 - nature.com
Invasive lobular carcinoma (ILC) is the second most common breast cancer subtype and
accounts for 8–14% of all cases. Although the majority of human ILCs are characterized by …
accounts for 8–14% of all cases. Although the majority of human ILCs are characterized by …
Distinct shared and compartment-enriched oncogenic networks drive primary versus metastatic breast cancer
Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship
between oncogenic drivers that promote metastatic versus primary cancer is still …
between oncogenic drivers that promote metastatic versus primary cancer is still …
Chromatin landscapes of retroviral and transposon integration profiles
The ability of retroviruses and transposons to insert their genetic material into host DNA
makes them widely used tools in molecular biology, cancer research and gene therapy …
makes them widely used tools in molecular biology, cancer research and gene therapy …
Cancer gene discovery: exploiting insertional mutagenesis
M Ranzani, S Annunziato, DJ Adams, E Montini - Molecular cancer research, 2013 - AACR
Insertional mutagenesis has been used as a functional forward genetics screen for the
identification of novel genes involved in the pathogenesis of human cancers. Different …
identification of novel genes involved in the pathogenesis of human cancers. Different …
From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets
C Eifert, RS Powers - Nature reviews cancer, 2012 - nature.com
The analysis of human cancer by genome sequencing and various types of arrays has
proved that many tumours harbour hundreds of genes that are mutated or substantially …
proved that many tumours harbour hundreds of genes that are mutated or substantially …