Sleep spindles: mechanisms and functions

LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

An emerging circuit pharmacology of GABAA receptors

E Engin, RS Benham, U Rudolph - Trends in pharmacological sciences, 2018 - cell.com
In the past 20 years we have learned a great deal about GABA A receptor (GABA AR)
subtypes, and which behaviors are regulated or which drug effects are mediated by each …

Structure, function, and plasticity of GABA transporters

A Scimemi - Frontiers in cellular neuroscience, 2014 - frontiersin.org
GABA transporters belong to a large family of neurotransmitter: sodium symporters. They are
widely expressed throughout the brain, with different levels of expression in different brain …

Thalamic inhibition: diverse sources, diverse scales

MM Halassa, L Acsády - Trends in neurosciences, 2016 - cell.com
The thalamus is the major source of cortical inputs shaping sensation, action, and cognition.
Thalamic circuits are targeted by two major inhibitory systems: the thalamic reticular nucleus …

Co-transmission of acetylcholine and GABA regulates hippocampal states

VT Takács, C Cserép, D Schlingloff, B Pósfai… - Nature …, 2018 - nature.com
The basal forebrain cholinergic system is widely assumed to control cortical functions via
non-synaptic transmission of a single neurotransmitter. Yet, we find that mouse hippocampal …

Tapping the brakes: cellular and synaptic mechanisms that regulate thalamic oscillations

PM Fogerson, JR Huguenard - Neuron, 2016 - cell.com
Thalamic oscillators contribute to both normal rhythms associated with sleep and anesthesia
and abnormal, hypersynchronous oscillations that manifest behaviorally as absence …

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

E Iavarone, J Simko, Y Shi, M Bertschy… - Cell Reports, 2023 - cell.com
Thalamoreticular circuitry plays a key role in arousal, attention, cognition, and sleep
spindles, and is linked to several brain disorders. A detailed computational model of mouse …

Region-selective control of the thalamic reticular nucleus via cortical layer 5 pyramidal cells

N Hádinger, E Bősz, B Tóth, G Vantomme, A Lüthi… - Nature …, 2023 - nature.com
Corticothalamic pathways, responsible for the top-down control of the thalamus, have a
canonical organization such that every cortical region sends output from both layer 6 (L6) …

Thalamic reticular control of local sleep in mouse sensory cortex

LMJ Fernandez, G Vantomme, A Osorio-Forero… - Elife, 2018 - elifesciences.org
Sleep affects brain activity globally, but many cortical sleep waves are spatially confined.
Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms …

[HTML][HTML] EEG spectral exponent as a synthetic index for the longitudinal assessment of stroke recovery

J Lanzone, MA Colombo, S Sarasso, F Zappasodi… - Clinical …, 2022 - Elsevier
Abstract Objective Quantitative Electroencephalography (qEEG) can capture changes in
brain activity following stroke. qEEG metrics traditionally focus on oscillatory activity …