The aging and elderly population are particularly susceptible to cardiovascular disease. Age
is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are …

In clinical settings, oxygen therapy is administered to preterm neonates and to adults with
acute and chronic conditions such as COVID-19, pulmonary fibrosis, sepsis, cardiac arrest …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by
progressive lung impairment typically triggered by inflammatory processes. The mortality toll …

Background Cardiomyocyte size histomorphometry is widely required in myocardial
remodeling research, but it relies on subjective, time-consuming manual tracing. We aimed …

Hyperoxia exposure in mice leads to cardiac hypertrophy and voltage-gated potassium (Kv)
channel remodeling. Because redox balance of pyridine nucleotides affects Kv function and …

Preterm birth is a risk factor for cardiometabolic disease. The preterm heart before terminal
differentiation is in a phase that is crucial for the number and structure of cardiomyocytes in …

Hyperoxia is characterized by pronounced inflammatory responses, pulmonary cell
apoptosis, and adverse cardiac remodeling due to an excess supply of oxygen. Hyperoxic …

Mechanical ventilation with high oxygen therapy (hyperoxia) is widely implemented in
critical care and ICU settings. Although supplemental oxygen is beneficial to treat hypoxia …

New Findings What is the central question of this study? The goal of this study was to
evaluate sex differences and the role of the potassium channel β1 (Kvβ1) subunit in the …

Mechanical ventilation often results in hyperoxia, a condition characterized by excess SpO2
levels (> 96%). Hyperoxia results in changes in the physiological parameters, severe …