Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for
its role in contractile activation. However, in recent years the critical role of Ca in other …

Rationale: The success of cardiac stem cell therapies is limited by low cell retention, due at
least in part to washout via coronary veins. Objective: We sought to counter the efflux of …

Adult mammalian cardiomyocyte regeneration after injury is thought to be minimal.
Mononuclear diploid cardiomyocytes (MNDCMs), a relatively small subpopulation in the …

The human heart is believed to grow by enlargement but not proliferation of cardiomyocytes
(heart muscle cells) during postnatal development. However, recent studies have shown that …

Many organs rely on undifferentiated stem and progenitor cells for tissue regeneration.
Whether differentiated cells themselves can contribute to cell replacement and tissue …

Adult mammalian hearts respond to injury with scar formation and not with cardiomyocyte
proliferation, the cellular basis of regeneration. Although cardiogenic progenitor cells may …

Background: Adult mammalian hearts have a limited ability to generate new cardiomyocytes.
Proliferation of existing adult cardiomyocytes (ACMs) is a potential source of new …

Rationale: The transverse tubule (T-tubule) system is the ultrastructural substrate for
excitation–contraction coupling in ventricular myocytes; T-tubule disorganization and loss …

Rationale: A major goal for the treatment of heart tissue damaged by cardiac injury is to
develop strategies for restoring healthy heart muscle through the regeneration and repair of …

Cardiosphere‐derived cells (CDCs) have been shown to regenerate infarcted myocardium
in patients after myocardial infarction (MI). However, whether the cells of the newly formed …