Site-specific protein modification is a widely-used biochemical tool. However, there are
many challenges associated with the development of protein modification techniques, in …

Iron is an essential nutrient for both humans and pathogenic microbes. Because of its ability
to exist in one of two oxidation states, iron is an ideal redox catalyst for diverse cellular …

Bacterial pathogens require the iron-containing cofactor heme to cause disease. Heme is
essential to the function of hemoproteins, which are involved in energy generation by the …

We determined the complete genome sequence of Clostridium difficile strain 630, a virulent
and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the …

Recent progress in elucidating the role of the icaADBC-encoded polysaccharide
intercellular adhesin (PIA) or polymeric N-acetyl-glucosamine (PNAG) in staphylococcal …

The cell wall envelopes of gram-positive bacteria represent a surface organelle that not only
functions as a cytoskeletal element but also promotes interactions between bacteria and …

In Gram‐positive bacteria proteins are displayed on the cell surface using sortase enzymes.
These cysteine transpeptidases join proteins bearing an appropriate sorting signal to …

Iron is a versatile redox-active catalyst and a required cofactor within a diverse array of
biological processes. To almost all organisms, iron is both essential and potentially toxic …

Device-associated infections involving biofilm remain a persistent clinical problem. We
recently reported that four methicillin-resistant Staphylococcus aureus (MRSA) strains …

Secretory proteins perform a variety of important “remote-control” functions for bacterial
survival in the environment. The availability of complete genome sequences has allowed us …