An update on the epidemiology of type 2 diabetes: a global perspective

MG Tinajero, VS Malik - Endocrinology and Metabolism Clinics, 2021 - endo.theclinics.com
Type 2 diabetes (T2D) is a chronic health condition that has reached alarming rates across
the globe. A little more than 2 decades ago, the International Diabetes Federation (IDF) …

[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease

KR Tuttle, R Agarwal, CE Alpers, GL Bakris… - Kidney international, 2022 - Elsevier
Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

Carboxymethyl chitosan-based hydrogels containing fibroblast growth factors for triggering diabetic wound healing

Y Hao, W Zhao, H Zhang, W Zheng, Q Zhou - Carbohydrate Polymers, 2022 - Elsevier
Triggering the repair process of diabetic wounds is a huge clinical challenge due to
microbial infection, the reduced migration and proliferation of fibroblasts, decreased …

[HTML][HTML] Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Z Luo, M Tian, G Yang, Q Tan, Y Chen, G Li… - … and Targeted Therapy, 2022 - nature.com
Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Combined antioxidant–antibiotic treatment for effectively healing infected diabetic wounds based on polymer vesicles

T Wang, Y Li, EJ Cornel, C Li, J Du - ACS nano, 2021 - ACS Publications
Infected diabetic wounds are difficult to heal due to high reactive oxygen species (ROS)
concentrations and recurrent infections. Such wounds can easily deteriorate into a diabetic …

Specific nanodrug for diabetic chronic wounds based on antioxidase-mimicking MOF-818 nanozymes

D Chao, Q Dong, Z Yu, D Qi, M Li, L Xu… - Journal of the …, 2022 - ACS Publications
Chronic wound is a common complication for diabetic patients, which entails substantial
inconvenience, persistent pain, and significant economic burden to patients. However …

Complexities of the glomerular basement membrane

RW Naylor, MRPT Morais, R Lennon - Nature Reviews Nephrology, 2021 - nature.com
The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …

Therapeutic targets, novel drugs, and delivery systems for diabetes associated NAFLD and liver fibrosis

V Kumar, X Xin, J Ma, C Tan, N Osna… - Advanced Drug Delivery …, 2021 - Elsevier
Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the
fourth-leading cause of death. Hyperglycemia induces various complications, including …

Extracellular matrix‐based conductive interpenetrating network hydrogels with enhanced neurovascular regeneration properties for diabetic wounds repair

L Fan, C Xiao, P Guan, Y Zou, H Wen… - Advanced …, 2022 - Wiley Online Library
The critical effects that impair diabetic wound healing are characterized by poor
vascularization and severe peripheral neuropathy. Current management strategies for …

Multifunctional silk fibroin methacryloyl microneedle for diabetic wound healing

G Guan, Q Zhang, Z Jiang, J Liu, J Wan, P Jin, Q Lv - Small, 2022 - Wiley Online Library
Diabetic wound is one of the common complications in diabetic patients, which exhibits
chronic, hard‐to‐heal characteristics. The healing process of wounds is impaired by several …