Molecular imaging for cancer diagnosis and surgery

T Hussain, QT Nguyen - Advanced drug delivery reviews, 2014 - Elsevier
Novel molecular imaging techniques have the potential to significantly enhance the
diagnostic and therapeutic approaches for cancer treatment. For solid tumors in particular …

Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents

C Shen, EJ New - Current opinion in chemical biology, 2013 - Elsevier
Magnetic resonance imaging is a powerful imaging modality that is often coupled with
paramagnetic contrast agents based on gadolinium to enhance sensitivity and image …

Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI‐CEST pH‐responsive contrast agent

DL Longo, A Busato, S Lanzardo… - Magnetic resonance …, 2013 - Wiley Online Library
Purpose To investigate in vivo possible pH level alterations following an acute renal failure
disease using a MRI‐CEST pH responsive contrast agent. The impact of functional evolution …

[HTML][HTML] An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancer

Y Sun, B Lyu, C Yang, B He, H Zhang, X Wang… - Bioactive Materials, 2023 - Elsevier
Mild photothermal therapy combined with immune checkpoint blockade has received
increasing attention for the treatment of advanced or metastatic cancers due to its good …

Biodegradable polydisulfide dendrimer nanoclusters as MRI contrast agents

CH Huang, K Nwe, A Al Zaki, MW Brechbiel… - Acs Nano, 2012 - ACS Publications
Gadolinium-conjugated dendrimer nanoclusters (DNCs) are a promising platform for the
early detection of disease; however, their clinical utility is potentially limited due to safety …

Synthesis of high relaxivity gadolinium AAZTA tetramers as building blocks for bioconjugation

M Tripepi, F Capuana, E Gianolio, FVC Kock… - Bioconjugate …, 2018 - ACS Publications
Molecular imaging requires the specific accumulation of contrast agents at the target. To
exploit the superb resolution of MRI for applications in molecular imaging, gadolinium …

[HTML][HTML] A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (499 views)

V Catanzaro, CV Gringeri, V Menchise… - Angew Chem Int Ed …, 2013 - ibb.cnr.it
Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the
activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a …

A comprehensive review on controls in molecular imaging: lessons from MMP‐2 imaging

R Lebel, M Lepage - Contrast media & molecular imaging, 2014 - Wiley Online Library
Metalloproteinases (MMPs), including MMP‐2, play critical roles in tissue remodeling and
are involved in a large array of pathologies, including cancer, arthritis and atherosclerosis …

MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch

GG Westmeyer, Y Emer, J Lintelmann, A Jasanoff - Chemistry & biology, 2014 - cell.com
The ability to map patterns of gene expression noninvasively in living animals could have
impact in many areas of biology. Reporter systems compatible with MRI could be particularly …

Gd-labeled glycol chitosan as a pH-responsive magnetic resonance imaging agent for detecting acidic tumor microenvironments

K Nwe, CH Huang, A Tsourkas - Journal of medicinal chemistry, 2013 - ACS Publications
Neoplastic lesions can create a hostile tumor microenvironment with low extracellular pH. It
is commonly believed that these conditions can contribute to tumor progression as well as …