βAR-mTOR-lipin1 pathway mediates PKA-RIIβ deficiency-induced adipose browning
B Wang, Z Hu, L Cui, M Zhao, Z Su, Y Jiang… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: Enhancing white adipose tissue (WAT) browning combats obesity. The RIIβ
subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and …
subunit of cAMP-dependent protein kinase (PKA) is primarily expressed in the brain and …
Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets
Background Delineating the shared genetic architecture of type 2 diabetes with muscle
mass and function and frailty is essential for unraveling the common etiology and …
mass and function and frailty is essential for unraveling the common etiology and …
[HTML][HTML] Les voies de signalisation régulées par la disponibilité en acides aminés: contrôle de fonctions physiologiques et impacts en santé
P Fafournoux - Médecine des Maladies Métaboliques, 2024 - Elsevier
Résumé Chez les mammifères, la capacité de synthétiser tous les acides aminés (AA) n'a
pas été conservée par l'évolution. Neuf acides aminés indispensables (AAI), doivent …
pas été conservée par l'évolution. Neuf acides aminés indispensables (AAI), doivent …
[HTML][HTML] Why We Age: Deregulated Nutrient Sensing
S Rose - Cell, 2024 - lifespan.io
Aging is a combination of complex processes influenced by various biological pathways,
one of which is the regulation of nutrient sensing. The “Hallmarks of Aging” framework …
one of which is the regulation of nutrient sensing. The “Hallmarks of Aging” framework …
[DOC][DOC] Arginase 1 promotes hepatic lipogenesis by regulating ERK2/PPARγ signaling in a non-canonical manner
Y Shi, M Shao, X Cao, Y Chen, Z Zhu, Y Shu, Q Tao… - 2025 - assets-eu.researchsquare.com
The global incidence of obesity and its metabolic sequelae, notably metabolic dysfunction-
associated steatohepatitis (MASLD), has escalated to epidemic levels. We unveil a …
associated steatohepatitis (MASLD), has escalated to epidemic levels. We unveil a …
Cellular, Molecular and Metabolic Variation Resulting From Skeletal-Muscle Specific High-Expression of the Thyroid Hormone Binding Protein Mu-Crystallin are Sex …
K Noland - 2024 - search.proquest.com
The prevalence of obesity continues to rise globally while traditional modalities such as
dietary change, increase in physical activity, and behavioral therapy are often insufficient …
dietary change, increase in physical activity, and behavioral therapy are often insufficient …