Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview
The histone deacetylases (HDACs) enzymes provided crucial role in transcriptional
regulation of cells through deacetylation of nuclear histone proteins. Discoveries related to …
regulation of cells through deacetylation of nuclear histone proteins. Discoveries related to …
Recent updates on thienopyrimidine derivatives as anticancer agents
Thienopyrimidine derivatives hold a unique place between fused pyrimidine compounds.
They are important and widely represented in medicinal chemistry as they are structural …
They are important and widely represented in medicinal chemistry as they are structural …
[HTML][HTML] Dipeptidyl peptidase-IV inhibitory action of Calebin A: an in silico and in vitro analysis
Abstract Background Dipeptidyl peptidase-IV (DPP-IV) inhibitors, the enhancers of incretin
are used for the treatment of diabetes. The non-glycaemic actions of these drugs (under …
are used for the treatment of diabetes. The non-glycaemic actions of these drugs (under …
Combined pharmacophore modeling, 3D-QSAR and docking studies to identify novel HDAC inhibitors using drug repurposing
J Liu, Y Zhu, Y He, H Zhu, Y Gao, Z Li… - Journal of …, 2020 - Taylor & Francis
Histone deacetylases (HDACs), a critical family of epigenetic enzymes, has emerged as a
promising target for antitumor drugs. Here, we describe our protocol of virtual screening in …
promising target for antitumor drugs. Here, we describe our protocol of virtual screening in …
HDAC8 as a target in drug discovery: function, structure and design
Q Zhao, H Liu, J Peng, H Niu, J Liu, H Xue… - European Journal of …, 2024 - Elsevier
Histone deacetylases (HDACs) have emerged as prominent therapeutic targets in drug
discovery. Among the members of the HDAC family, HDAC8 exhibits distinct structural and …
discovery. Among the members of the HDAC family, HDAC8 exhibits distinct structural and …
Recent prospectives of anticancer histone deacetylase inhibitors
SA Abbass, HA Hassan… - Journal of …, 2019 - jabps.journals.ekb.eg
Histone deacetylases (HDACs) are common targets for cancer therapy as they are
expressed in many forms of cancers; several research studies have been introduced …
expressed in many forms of cancers; several research studies have been introduced …
Conformal prediction of HDAC inhibitors
The growing interest in epigenetic probes and drug discovery, as revealed by several
epigenetic drugs in clinical use or in the lineup of the drug development pipeline, is boosting …
epigenetic drugs in clinical use or in the lineup of the drug development pipeline, is boosting …
Discovery of novel HDAC8 inhibitors from natural compounds by in silico high throughput screening
SM Esther Rubavathy, K Palanisamy… - Journal of …, 2023 - Taylor & Francis
A class I histone deacetylase HDAC8 is associated with several diseases, including cancer,
intellectual impairment and parasite infection. Most of the HDAC inhibitors that have so far …
intellectual impairment and parasite infection. Most of the HDAC inhibitors that have so far …
Unveiling critical structural features for effective HDAC8 inhibition: a comprehensive study using quantitative read-across structure–activity relationship (q-RASAR) …
Histone deacetylases constitute a group of enzymes that participate in several biological
processes. Notably, inhibiting HDAC8 has become a therapeutic strategy for various …
processes. Notably, inhibiting HDAC8 has become a therapeutic strategy for various …
[PDF][PDF] Docking Study, Synthesis, Characterization and Preliminary Cytotoxic Evaluation of New 1, 3, 4-Thiadiazole Derivatives.
NM Mohammed, MH Mohammed… - Journal of Contemporary …, 2023 - iasj.net
Objectives: This study has determined that these newly synthesized analogs hold promise
as potential sources of novel anticancer agents for combating breast cancer. Methods: We …
as potential sources of novel anticancer agents for combating breast cancer. Methods: We …