Carcinogenesis cannot be explained only by genetic alterations, but also involves
epigenetic processes. Modification of histones by acetylation plays a key role in epigenetic …

Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream
with Janus kinases (JAK) family protein and capable of integrating inputs from different …

Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

Histone deacetylases (HDACs) are enzymes that play a key role in the epigenetic regulation
of gene expression by remodeling chromatin. Inhibition of HDACs is a prospective …

RUNX proteins belong to a family of metazoan transcription factors that serve as master
regulators of development. They are frequently deregulated in human cancers, indicating a …

ABSTRACT RUNX transcription factors orchestrate many different aspects of biology,
including basic cellular and developmental processes, stem cell biology and tumorigenesis …

p53 is a nuclear transcription factor with a pro-apoptotic function. Since over 50% of human
cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of …

Histone deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …

Gastric cancer remains one of the most common cancers worldwide and one of the leading
cause for cancer-related deaths. Gastric adenocarcinoma is a multifactorial disease that is …

Background Analyses of microRNA expression profiles have shown that many microRNAs
are expressed aberrantly and correlate with tumorigenesis, progression, and prognosis of …