X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

Summary The lncRNA Xist forms∼ 50 diffraction-limited foci to transcriptionally silence one
X chromosome. How this small number of RNA foci and interacting proteins regulate a much …

Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …

The X inactive-specific transcript (Xist) gene is the master regulator of X chromosome
inactivation in mammals. Xist produces a long noncoding (lnc) RNA that accumulates over …

Development is a complex process regulated both by genetic and epigenetic and
environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key …

As an oncogenic transcription factor, Yin Yang 1 (YY1) regulates enhancer and promoter
connection. However, gaps still exist in understanding how YY1 coordinates coactivators …

Aberrant expression of XIST, a long noncoding RNA (lncRNA) initiating X chromosome
inactivation (XCI) in early embryogenesis, is a common feature of breast cancer (BC) …

Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which
lays the foundation for gametogenesis, totipotency, and embryonic development. We …