Organoids and stem-cell-based embryo models (SEMs) are imperfect organ or embryo
representations that explore a much larger space of possible forms, or morphospace …

Organ morphogenesis is multifaceted, multiscale, and fundamentally a robust process.
Despite the complex and dynamic nature of embryonic development, organs are built with …

Failure in the elongation of the cardiac outflow tract (OFT) results in congenital heart disease
due to the misalignment of the great arteries with the left and right ventricles. The OFT …

Quantifying cell biology in space and time requires computational methods to detect cells,
measure their properties, and assemble these into meaningful trajectories. In this aspect …

Transcription factors (TFs) are DNA-binding proteins able to modulate the timing, location,
and levels of gene expression by binding to regulatory DNA regions. Therefore, the …

The vertebrate heart tube extends by progressive addition of epithelial second heart field
(SHF) progenitor cells from the dorsal pericardial wall. The interplay between epithelial …

The emergence of new structures can often be linked to the evolution of novel cell types that
follows the rewiring of developmental gene regulatory subnetworks. Vertebrates are …

Introduction Differentiation of spore mother cells marks the somatic-to-reproductive transition
in higher plants. Spore mother cells are critical for fitness because they differentiate into …

Neural crest (NC) is a vertebrate-specific embryonic progenitor cell population at the basis of
important vertebrate features such as the craniofacial skeleton and pigmentation patterns …

Motivation The shape of a cell is tightly controlled, and reflects important processes
including actomyosin activity, adhesion properties, cell differentiation, and polarization …