The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77
members known in the human, most of which consist of a RING-finger domain, one or two B …

Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …

The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are
unusually diverse with regard to their chromatin features, including histone modifications …

Myelodysplastic syndrome and acute myeloid leukemia (AML) belong to a continuous
disease spectrum of myeloid malignancies with poor prognosis in the relapsed/refractory …

Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with
no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients …

RB transcriptional corepressor 1 (RB) deletion is the most important genomic factor
associated with the prognosis of castration-resistant prostate cancer (CRPC) patients …

Breast cancer (BC) is considered one of the most prevalent malignancies impacting women
worldwide, constituting 15% of all new cancer cases. It is classified according to its …

The factors driving glioma progression remain poorly understood. Here, the epigenetic
regulator TRIM24 is identified as a driver of glioma progression, where TRIM24 …

Reprogramming of macrophages toward an M1 phenotype is a novel strategy to induce
anticancer immunity. However, the regulatory mechanisms of M1 macrophage polarization …

Triple-negative breast cancer (TNBC) represents roughly one-sixth of all breast cancer
patients, but accounts for 30–40% of breast cancer deaths. Due to the lack of typical …