Structural biology and molecular pharmacology of voltage-gated ion channels
Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …
permeate ions across the cell membrane in response to changes in membrane potential …
Medicinal plants for epileptic seizures: Phytoconstituents, pharmacology and mechanisms revisited
X He, X Chen, Y Yang, Y Xie, Y Liu - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Epilepsy is a neurological disorder that presents with
recurring and spontaneous seizures. It is prevalent worldwide, affecting up to 65 million …
recurring and spontaneous seizures. It is prevalent worldwide, affecting up to 65 million …
Dual-pocket inhibition of Nav channels by the antiepileptic drug lamotrigine
Voltage-gated sodium (Nav) channels govern membrane excitability, thus setting the
foundation for various physiological and neuronal processes. Nav channels serve as the …
foundation for various physiological and neuronal processes. Nav channels serve as the …
Ligand activation mechanisms of human KCNQ2 channel
D Ma, Y Zheng, X Li, X Zhou, Z Yang, Y Zhang… - Nature …, 2023 - nature.com
The human voltage-gated potassium channel KCNQ2/KCNQ3 carries the neuronal M-
current, which helps to stabilize the membrane potential. KCNQ2 can be activated by …
current, which helps to stabilize the membrane potential. KCNQ2 can be activated by …
Structural basis for human Cav1. 2 inhibition by multiple drugs and the neurotoxin calciseptine
Ca v 1.2 channels play crucial roles in various neuronal and physiological processes. Here,
we present cryo-EM structures of human Ca v 1.2, both in its apo form and in complex with …
we present cryo-EM structures of human Ca v 1.2, both in its apo form and in complex with …
Drugs exhibit diverse binding modes and access routes in the Nav1. 5 cardiac sodium channel pore
E Tao, B Corry - Journal of General Physiology, 2025 - rupress.org
Small molecule inhibitors of the sodium channel are common pharmacological agents used
to treat a variety of cardiac and nervous system pathologies. They act on the channel via …
to treat a variety of cardiac and nervous system pathologies. They act on the channel via …
Neuropathic Pain, Mood, and Stress-Related Disorders: A Literature Review of Comorbidity and Co-Pathogenesis
WF Vieira, DRA Coelho, ST Litwiler… - Neuroscience & …, 2024 - Elsevier
Neuropathic pain can be caused by multiple factors, and its prevalence can reach 10% of
the global population. It is becoming increasingly evident that limited or short-lasting …
the global population. It is becoming increasingly evident that limited or short-lasting …
A versatile residue numbering scheme for Nav and Cav channels
Voltage-gated sodium (Na v) and calcium (Ca v) channels are responsible for the initiation
of electrical signals. They have long been targeted for the treatment of various diseases. The …
of electrical signals. They have long been targeted for the treatment of various diseases. The …
Cannabis constituents for chronic neuropathic pain; reconciling the clinical and animal evidence
E Sokolaj, N Assareh, K Anderson… - Journal of …, 2024 - Wiley Online Library
Chronic neuropathic pain is a debilitating pain syndrome caused by damage to the nervous
system that is poorly served by current medications. Given these problems, clinical studies …
system that is poorly served by current medications. Given these problems, clinical studies …
Cannabidiol and brain function: current knowledge and future perspectives
Cannabidiol (CBD) is a naturally occurring non-psychoactive cannabinoid found in
Cannabis sativa, commonly known as cannabis or hemp. Although currently available CBD …
Cannabis sativa, commonly known as cannabis or hemp. Although currently available CBD …