The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

Numerous analyses of large patient cohorts identified specific patterns of immune activation
associated with patient survival. We established these as the immune contexture …

Combining DNA-demethylating agents (DNA methyltransferase inhibitors [DNMTis]) with
histone deacetylase inhibitors (HDACis) holds promise for enhancing cancer immune …

A complex network of chemokines and their receptors influences the development of primary
tumours and metastases. New information about the biological role of chemokines in these …

Purpose To detect a pretreatment gene expression signature (GS) predictive of response to
MAGE-A3 immunotherapeutic in patients with metastatic melanoma and to investigate its …

Lung cancer remains a serious public health problem and is the first cause of cancer death
worldwide, and the overall 5-year survival rate for all stages is 14–17% for Non-small-cell …

Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …

Immune system–mediated eradication of neoplastic cells requires induction of a strong long-
lasting antitumor T-cell response. However, generation of tumor-specific effector T cells does …

Inflammatory cell infiltration of tumors contributes either positively or negatively to tumor
invasion, growth, metastasis, and patient outcomes, creating a Dr. Jekyll or Mr. Hyde …

Immunotherapies have shown considerable efficacy for the treatment of various cancers, but
a multitude of patients remain unresponsive for various reasons, including poor homing of T …