Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

Whereas T cells in the tumor microenvironment have been the main focus as cancer
controlling cells and targets of immunotherapies, B cells have recently gained strong …

Dimeric IgA (dIgA) can move through cells via the IgA/IgM polymeric immunoglobulin
receptor (PIGR), which is expressed mainly on mucosal epithelia. Here, we studied the …

Immuno-oncology has traditionally focused on the cellular arm of the adaptive immune
response, while attributing tumor-promoting activity to humoral responses in tumor-bearing …

The tumor microenvironment (TME) is a complex and heterogeneous tissue composed of
various cell types, including tumor cells, stromal cells, and immune cells, as well as non …

Genomic instability is a driver and accelerator of tumorigenesis and influences disease
outcomes across cancer types. Although genomic instability has been associated with …

Inflammatory response is an important feature of most tumors. Local inflammation promotes
tumor cell immune evasion and chemotherapeutic drug resistance. We aimed to build a …

Endometrial cancer is rising in prevalence. The standard treatment modality of hysterectomy
is becoming increasingly inadequate due primarily to the direct link between endometrial …

Background p53, the most frequently mutated gene in cancer, lacks effective targeted drugs.
Methods We developed monoclonal antibodies (mAbs) that target a p53 hotspot mutation …

Background Endometrial cancer (EC) is one of the worldwide gynecological malignancies.
Endoplasmic reticulum (ER) stress is the cellular homeostasis disturbance that participates …