Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

The role of oxidative stress in the physiopathology of human pregnancy is of particular
interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a …

The generation of reactive oxygen species (ROS) plays an important role for the
maintenance of cellular processes and functions in the body. However, the excessive …

Classical activation of macrophages (M (LPS+ IFNγ)) elicits the expression of inducible nitric
oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial …

Ion-exchange chromatography (IEC) is a chromatographic technique commonly used for the
separation of ions and ionizable molecules. Its direct coupling with mass spectrometry has …

Cellular redox homeostasis is an essential, dynamic process that ensures the balance
between reducing and oxidizing reactions within cells and thus has implications across all …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder of the
central nervous system after Alzheimer's disease. The current understanding of PD focuses …

Reactive oxygen species (ROS; eg., superoxide [O2•−] and hydrogen peroxide [H2O2]) and
reactive nitrogen species (RNS; eg., nitric oxide [NO•]) at the physiological level function as …

Preeclampsia is a multisystemic disorder of pregnancy that causes perinatal morbidity and
mortality. Studies published in the last decade have contributed to a better understanding of …