Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation
G Fisher, M Corbella, MS Alphey, J Nicholson… - Nature …, 2022 - nature.com
ATP phosphoribosyltransferase catalyses the first step of histidine biosynthesis and is
controlled via a complex allosteric mechanism where the regulatory protein HisZ enhances …
controlled via a complex allosteric mechanism where the regulatory protein HisZ enhances …
Crystal Structure, Steady-State, and Pre-Steady-State Kinetics of Acinetobacter baumannii ATP Phosphoribosyltransferase
BJ Read, AF Cadzow, MS Alphey, JBO Mitchell… - Biochemistry, 2023 - ACS Publications
The first step of histidine biosynthesis in Acinetobacter baumannii, the condensation of ATP
and 5-phospho-α-d-ribosyl-1-pyrophosphate to produce N 1-(5-phospho-β-d-ribosyl)-ATP …
and 5-phospho-α-d-ribosyl-1-pyrophosphate to produce N 1-(5-phospho-β-d-ribosyl)-ATP …
Host-Induced Gene Silencing of an Adenylate Kinase Gene Involved in Fungal Energy Metabolism Improves Plant Resistance to Verticillium dahliae
Verticillium wilt, caused by the ascomycete fungus Verticillium dahliae (Vd), is a devastating
disease of numerous plant species. However, the pathogenicity/virulence-related genes in …
disease of numerous plant species. However, the pathogenicity/virulence-related genes in …
Allosteric activation unveils protein-mass modulation of ATP phosphoribosyltransferase product release
Heavy-isotope substitution into enzymes slows down bond vibrations and may alter
transition-state barrier crossing probability if this is coupled to fast protein motions. ATP …
transition-state barrier crossing probability if this is coupled to fast protein motions. ATP …
Allosteric Inhibition of Acinetobacter baumannii ATP Phosphoribosyltransferase by Protein:Dipeptide and Protein:Protein Interactions
BJ Read, G Fisher, OLR Wissett… - ACS Infectious …, 2021 - ACS Publications
ATP phosphoribosyltransferase (ATPPRT) catalyzes the first step of histidine biosynthesis in
bacteria, namely, the condensation of ATP and 5-phospho-α-d-ribosyl-1-pyrophosphate …
bacteria, namely, the condensation of ATP and 5-phospho-α-d-ribosyl-1-pyrophosphate …
A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase
Adenosine triphosphate (ATP) phosphoribosyltransferase (ATP-PRT) catalyses the first
committed step of histidine biosynthesis in plants and microorganisms. Two forms of ATP …
committed step of histidine biosynthesis in plants and microorganisms. Two forms of ATP …
Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase
G Fisher, CM Thomson, R Stroek, CM Czekster… - Biochemistry, 2018 - ACS Publications
Short-form ATP phosphoribosyltransferase (ATPPRT) is a hetero-octameric allosteric
enzyme comprising four catalytic subunits (HisGS) and four regulatory subunits (HisZ) …
enzyme comprising four catalytic subunits (HisGS) and four regulatory subunits (HisZ) …
Transition state analysis of adenosine triphosphate phosphoribosyltransferase
Adenosine triphosphate phosphoribosyltransferase (ATP-PRT) catalyzes the first step in
histidine biosynthesis, a pathway essential to microorganisms and a validated target for …
histidine biosynthesis, a pathway essential to microorganisms and a validated target for …
Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase
MS Alphey, G Fisher, Y Ge, ER Gould… - ACS …, 2018 - ACS Publications
Allosteric modulation of catalysis is a common regulatory strategy of flux-controlling
biosynthetic enzymes. The enzyme ATP phosphoribosyltransferase (ATPPRT) catalyzes the …
biosynthetic enzymes. The enzyme ATP phosphoribosyltransferase (ATPPRT) catalyzes the …
Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase
R Stroek, Y Ge, PD Talbot, MK Glok, KE Bernaś… - Biochemistry, 2017 - ACS Publications
Adenosine 5′-triphosphate phosphoribosyltransferase (ATPPRT) catalyzes the first step in
histidine biosynthesis, the condensation of ATP and 5-phospho-α-d-ribosyl-1 …
histidine biosynthesis, the condensation of ATP and 5-phospho-α-d-ribosyl-1 …