Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

Background Autophagy is an intracellular degradation system that removes unnecessary or
dysfunctional components and recycles them for other cellular functions. Over the years, a …

SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

In response to lysosomal damage, cells engage several quality-control mechanisms,
including the selective isolation and degradation of damaged lysosomes by lysophagy …

Cisplatin (CP) is a well-known chemotherapeutic agent with excellent clinical effects. The
anti-tumor activity of CP has been demonstrated in different cancers such as breast, cervical …

Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …

Excessive and prolonged neuroinflammation following traumatic brain injury (TBI)
contributes to long-term tissue damage and poor functional outcomes. However, the …

TRIM21 (Ro52/SSA1) is an E3 ubiquitin ligase with key roles in immune host defence, signal
transduction, and possibly cell cycle regulation. It is also an autoantibody target in Sjögren's …

Background: Pathological cardiac hypertrophy is one of the leading causes of heart failure
with highly complicated pathogeneses. The E3 ligase TRIM16 (tripartite motif–containing …

The tumor suppressor TP53 is the most frequently mutated gene in human cancers. Mutant
p53 (mutp53) proteins often accumulate to very high levels in human cancers to promote …