A general consensus exists that IBD is associated with compositional and metabolic
changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship …

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

Interleukin 10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in the control of
immune responses. However, its mechanisms of action remain poorly understood. Here, we …

Recent advances in sequencing techniques, applied to the study of microbial communities,
have provided compelling evidence that the mammalian intestinal tract harbors a complex …

The barrier surfaces of the gastrointestinal tract are in constant contact with various
microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the …

Commensal gut microflora and dietary fiber protect against colonic inflammation and colon
cancer through unknown targets. Butyrate, a bacterial product from fermentation of dietary …

The understanding of the intestinal inflammation occurring in the inflammatory bowel
diseases (IBD) has been immeasurably advanced by the development of the now numerous …

The emergence of the adaptive immune system in vertebrates set the stage for evolution of
an advanced symbiotic relationship with the intestinal microbiota. The defining features of …

ABSTRACT Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that
plays a central role in limiting host immune response to pathogens, thereby preventing …

Summary Intact interleukin-10 receptor (IL-10R) signaling on effector and T regulatory (Treg)
cells are each independently required to maintain immune tolerance. Here we show that IL …