Regulation of mTORC1 by PI3K signaling
CC Dibble, LC Cantley - Trends in cell biology, 2015 - cell.com
The class I phosphoinositide 3-kinase (PI3K)–mechanistic target of rapamycin (mTOR)
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
CC Dibble, BD Manning - Nature cell biology, 2013 - nature.com
Flux through metabolic pathways is inherently sensitive to the levels of specific substrates
and products, but cellular metabolism is also managed by integrated control mechanisms …
and products, but cellular metabolism is also managed by integrated control mechanisms …
[HTML][HTML] Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
Summary mTORC1 promotes cell growth in response to nutrients and growth factors. Insulin
activates mTORC1 through the PI3K-Akt pathway, which inhibits the TSC1-TSC2-TBC1D7 …
activates mTORC1 through the PI3K-Akt pathway, which inhibits the TSC1-TSC2-TBC1D7 …
[HTML][HTML] Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
The mTORC1 kinase promotes growth in response to growth factors, energy levels, and
amino acids, and its activity is often deregulated in disease. The Rag GTPases interact with …
amino acids, and its activity is often deregulated in disease. The Rag GTPases interact with …
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either TSC1
or TSC2. The TSC1 and TSC2 gene products form a functional complex and inhibit …
or TSC2. The TSC1 and TSC2 gene products form a functional complex and inhibit …
[HTML][HTML] Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
Abstract Background: Tuberous Sclerosis Complex (TSC) is a genetic disorder that occurs
through the loss of heterozygosity of either TSC1 or TSC2, which encode Hamartin or …
through the loss of heterozygosity of either TSC1 or TSC2, which encode Hamartin or …
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
W Kolch - Biochemical Journal, 2000 - portlandpress.com
The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …
regulated kinase) pathway is at the heart of signalling networks that govern proliferation …
Rheb binds and regulates the mTOR kinase
X Long, Y Lin, S Ortiz-Vega, K Yonezawa, J Avruch - Current biology, 2005 - cell.com
Background: The target of rapamycin (TOR), in complex with the proteins raptor and LST8
(TOR complex 1), phosphorylates the p70S6K and 4E-BP1 to promote mRNA translation …
(TOR complex 1), phosphorylates the p70S6K and 4E-BP1 to promote mRNA translation …
Human RAS superfamily proteins and related GTPases
J Colicelli - Science's STKE, 2004 - science.org
The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger
family of at least 35 related human proteins. Using a somewhat broader definition of …
family of at least 35 related human proteins. Using a somewhat broader definition of …
Structural basis for the docking of mTORC1 on the lysosomal surface
The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth
in response to nutrients and growth factors. Nutrients promote its translocation to the …
in response to nutrients and growth factors. Nutrients promote its translocation to the …