Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
C Tay, A Tanaka, S Sakaguchi - Cancer Cell, 2023 - cell.com
Regulatory T cells (Tregs) are abundant in tumor tissues, raising a question of whether
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …
immunosuppressive tumor-infiltrating Tregs (TI-Tregs) can be selectively depleted or …
Resistance mechanisms to anti-PD cancer immunotherapy
The transformative success of antibodies targeting the PD-1 (programmed death 1)/B7-H1
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …
Single-cell eQTL mapping identifies cell type–specific genetic control of autoimmune disease
The human immune system displays substantial variation between individuals, leading to
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …
differences in susceptibility to autoimmune disease. We present single-cell RNA sequencing …
T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-
directed repair (HDR) using high concentrations of double-stranded DNA (dsDNA) with …
directed repair (HDR) using high concentrations of double-stranded DNA (dsDNA) with …
[HTML][HTML] A guide to cancer immunotherapy: from T cell basic science to clinical practice
AD Waldman, JM Fritz, MJ Lenardo - Nature Reviews Immunology, 2020 - nature.com
The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a
central focus for engaging the immune system in the fight against cancer. Basic science …
central focus for engaging the immune system in the fight against cancer. Basic science …
Recent advances in hyperthermia therapy‐based synergistic immunotherapy
The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy
against malignant tumors. Nanomaterial‐based photothermal therapy (PTT) and magnetic …
against malignant tumors. Nanomaterial‐based photothermal therapy (PTT) and magnetic …
Molecular pathways of colon inflammation induced by cancer immunotherapy
Checkpoint blockade with antibodies specific for the PD-1 and CTLA-4 inhibitory receptors
can induce durable responses in a wide range of human cancers. However, the …
can induce durable responses in a wide range of human cancers. However, the …
Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells
Chimeric antigen receptor (CAR) T cell therapy targeting CD19 has achieved tremendous
success treating B cell malignancies; however, some patients fail to respond due to poor …
success treating B cell malignancies; however, some patients fail to respond due to poor …
Regulatory T cells in cancer immunosuppression—implications for anticancer therapy
Y Togashi, K Shitara, H Nishikawa - Nature reviews Clinical oncology, 2019 - nature.com
Regulatory T (Treg) cells, an immunosuppressive subset of CD4+ T cells characterized by
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …
the expression of the master transcription factor forkhead box protein P3 (FOXP3), are a …