Human stem cell models to study host–virus interactions in the central nervous system
O Harschnitz, L Studer - Nature Reviews Immunology, 2021 - nature.com
Advancements in human pluripotent stem cell technology offer a unique opportunity for the
neuroimmunology field to study host–virus interactions directly in disease-relevant cells of …
neuroimmunology field to study host–virus interactions directly in disease-relevant cells of …
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages
Human genome variation contributes to diversity in neurodevelopmental outcomes and
vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require …
vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require …
Integrin αvβ5 internalizes Zika virus during neural stem cells infection and provides a promising target for antiviral therapy
We perform a CRISPR-Cas9 genome-wide screen in glioblastoma stem cells and identify
integrin αvβ5 as an internalization factor for Zika virus (ZIKV). Expression of αvβ5 is …
integrin αvβ5 as an internalization factor for Zika virus (ZIKV). Expression of αvβ5 is …
The 22q11. 2 region regulates presynaptic gene-products linked to schizophrenia
R Nehme, O Pietiläinen, M Artomov… - Nature …, 2022 - nature.com
It is unclear how the 22q11. 2 deletion predisposes to psychiatric disease. To study this, we
generated induced pluripotent stem cells from deletion carriers and controls and utilized …
generated induced pluripotent stem cells from deletion carriers and controls and utilized …
A pooled cell painting CRISPR screening platform enables de novo inference of gene function by self-supervised deep learning
Pooled CRISPR screening has emerged as a powerful method of mapping gene functions
thanks to its scalability, affordability, and robustness against well or plate-specific …
thanks to its scalability, affordability, and robustness against well or plate-specific …
A review of virus host factor discovery using CRISPR screening
The emergence of genome-scale forward genetic screening techniques, such as Haploid
Genetic screen and clustered regularly interspaced short palindromic repeats (CRISPR) …
Genetic screen and clustered regularly interspaced short palindromic repeats (CRISPR) …
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons
CG Sanchez, CM Acker, A Gray, M Varadarajan… - Communications …, 2021 - nature.com
Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20
distinct neurodegenerative diseases, including Alzheimer's disease, progressive …
distinct neurodegenerative diseases, including Alzheimer's disease, progressive …
[HTML][HTML] Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons
The maturation of neurons and the development of synapses, although emblematic of
neurons, also relies on interactions with astrocytes and other glia. Here, to study the role of …
neurons, also relies on interactions with astrocytes and other glia. Here, to study the role of …
Leveraging the genetic diversity of human stem cells in therapeutic approaches
M Tegtmeyer, R Nehme - Journal of Molecular Biology, 2022 - Elsevier
Since their discovery 15 years ago, human pluripotent stem cell (hPSC) technologies have
begun to revolutionize science and medicine, rapidly expanding beyond investigative …
begun to revolutionize science and medicine, rapidly expanding beyond investigative …
A multimodal and multifunctional CMOS cellular interfacing array for digital physiology and pathology featuring an ultra dense pixel array and reconfigurable sampling …
The article presents a fully integrated multimodal and multifunctional CMOS
biosensing/actuating array chip and system for multi-dimensional cellular/tissue …
biosensing/actuating array chip and system for multi-dimensional cellular/tissue …