Class I histone deacetylases (HDAC1–3) are histone lysine delactylases
C Moreno-Yruela, D Zhang, W Wei, M Bæk, W Liu… - Science …, 2022 - science.org
Lysine L-lactylation [K (L-la)] is a newly discovered histone mark stimulated under conditions
of high glycolysis, such as the Warburg effect. K (L-la) is associated with functions that are …
of high glycolysis, such as the Warburg effect. K (L-la) is associated with functions that are …
Mechanism-based inhibitors of SIRT2: structure–activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast …
Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer
chain acyl groups from post-translationally modified lysine residues. It affects diverse …
chain acyl groups from post-translationally modified lysine residues. It affects diverse …
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide‐Activated Sirtuin 7
JE Bolding, AL Nielsen, I Jensen… - Angewandte Chemie …, 2023 - Wiley Online Library
The sirtuins are NAD+‐dependent lysine deacylases, comprising seven isoforms (SIRT1–7)
in humans, which are involved in the regulation of a plethora of biological processes …
in humans, which are involved in the regulation of a plethora of biological processes …
Dethioacylation by sirtuins 1–3: considerations for drug design using mechanism-based sirtuin inhibition
N Rajabi, AL Nielsen, CA Olsen - ACS Medicinal Chemistry …, 2020 - ACS Publications
The sirtuin enzymes are potential drug targets for intervention in a series of diseases. Efforts
to inhibit enzymes of this class with thioamide-and thiourea-containing, substrate-mimicking …
to inhibit enzymes of this class with thioamide-and thiourea-containing, substrate-mimicking …
Kinetic characterization of inhibitors of histone deacetylases (HDACs) and sirtuins
C Moreno-Yruela, AS Madsen, CA Olsen - 2019 - researchsquare.com
Histone deacetylase (HDAC) inhibitors are employed for the treatment of lymphoma and are
under development against multiple other types of cancer and neurodegenerative diseases …
under development against multiple other types of cancer and neurodegenerative diseases …
Fluorogenic Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide Activated SIRT7
JE Bolding, AL Nielsen, I Jensen, LA Ryberg… - bioRxiv, 2023 - biorxiv.org
The sirtuins are NAD+-dependent lysine deacylases, comprising seven isoforms (SIRT1–7)
in humans, which are involved in the regulation of a plethora of biology, including gene …
in humans, which are involved in the regulation of a plethora of biology, including gene …
[PDF][PDF] Selective inhibitors of SIRT2 regulate perinuclear α-tubulin acetylation, migration, and invasion of breast cancer cells
ABSTRACT Sirtuin 2 (SIRT2) is a protein deacylase enzyme that has been reported to
remove both acetyl groups and longer chain acyl groups from lysine residues in post …
remove both acetyl groups and longer chain acyl groups from lysine residues in post …