Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

The shear-responsive transcription factor Krüppel-like factor 2 (KLF2) is a critical regulator of
endothelial gene expression patterns induced by atheroprotective flow. As microRNAs …

Atherosclerotic plaques are found at distinct locations in the arterial system, despite the
exposure to systemic risk factors of the entire vascular tree. From the study of arterial …

Objective—Cellular metabolism was recently shown to regulate endothelial cell phenotype
profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear …

Lymphatic valves are essential for efficient lymphatic transport, but the mechanisms of early
lymphatic-valve morphogenesis and the role of biomechanical forces are not well …

Atherosclerosis is the primary underlying cause of cardiovascular disease which
preferentially develops at arterial regions exposed to disturbed flow (DF), but much less at …

The endothelium forms a vast network that dynamically regulates vascular barrier function,
coagulation pathways and vasomotor tone. Microvascular endothelial cells are uniquely …

Atherosclerosis is one of the most common vascular disorders. Endothelial cell (EC)
dysfunction and vascular smooth muscle cell (VSMC) proliferation contributes to the …

Atherosclerosis is an inflammatory disease in which lipids accumulate on the walls of blood
vessels, thickening and clogging these vessels. It is well known that cell-to-cell …