Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

DR Beers, SH Appel - The Lancet Neurology, 2019 - thelancet.com
Neuroinflammation is a common pathological feature of many neurodegenerative diseases,
including amyotrophic lateral sclerosis (ALS), and is characterised by activated CNS …

Current and emerging disease‐modulatory therapies and treatment targets for multiple sclerosis

F Piehl - Journal of Internal Medicine, 2021 - Wiley Online Library
The treatment of multiple sclerosis (MS), the most common chronic inflammatory,
demyelinating and neurodegenerative disease of the central nervous system (CNS) …

Comprehensive research on past and future therapeutic strategies devoted to treatment of amyotrophic lateral sclerosis

B Sever, H Ciftci, H DeMirci, H Sever, F Ocak… - International journal of …, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …

Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomised clinical trial

G Maynard, R Kannan, J Liu, W Wang… - The Lancet …, 2023 - thelancet.com
Background Spinal cord injury (SCI) causes neural disconnection and persistent
neurological deficits, so axon sprouting and plasticity might promote recovery. Soluble Nogo …

Overlapping neuroimmune mechanisms and therapeutic targets in neurodegenerative disorders

F De Marchi, I Munitic, L Vidatic, E Papić, V Rački… - Biomedicines, 2023 - mdpi.com
Many potential immune therapeutic targets are similarly affected in adult-onset
neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD) …

Central nervous system demyelinating diseases: glial cells at the hub of pathology

VG Coutinho Costa, SES Araújo… - Frontiers in …, 2023 - frontiersin.org
Inflammatory demyelinating diseases (IDDs) are among the main causes of inflammatory
and neurodegenerative injury of the central nervous system (CNS) in young adult patients …

Gene therapy approach with an emphasis on growth factors: theoretical and clinical outcomes in neurodegenerative diseases

DGT Parambi, KS Alharbi, R Kumar, S Harilal… - Molecular …, 2022 - Springer
The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective

C Wong, M Stavrou, E Elliott, JM Gregory… - Brain …, 2021 - academic.oup.com
Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease.
Despite decades of clinical trials, effective disease-modifying drugs remain scarce. To …

The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future

HJ Wobst, KL Mack, DG Brown… - Medicinal research …, 2020 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by
progressive loss of muscle function. It is the most common adult‐onset form of motor neuron …

Amyotrophic lateral sclerosis clinical trials and interpretation of functional end points and fluid biomarkers: a review

JM Shefner, R Bedlack, JA Andrews, JD Berry… - JAMA …, 2022 - jamanetwork.com
Importance Clinical trial activity in amyotrophic lateral sclerosis (ALS) is dramatically
increasing; as a result, trial modifications have been introduced to improve efficiency …