Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine
Chloroquine (CQ) resistance (CQR) in Plasmodium falciparum originated from at least six
foci in South America, Asia, and Oceania. Malaria parasites from these locations exhibit …
foci in South America, Asia, and Oceania. Malaria parasites from these locations exhibit …
[HTML][HTML] Genetics of chloroquine-resistant malaria: a haplotypic view
The development and rapid spread of chloroquine resistance (CQR) in Plasmodium
falciparum have triggered the identification of several genetic target (s) in the P. falciparum …
falciparum have triggered the identification of several genetic target (s) in the P. falciparum …
A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan
AA Khattak, M Venkatesan, CG Jacob, EM Artimovich… - Malaria Journal, 2013 - Springer
Background Few studies have been conducted in Pakistan to determine the efficacy of
chloroquine and sulphadoxine-pyrimethamine (SP), which remain in use as treatment for …
chloroquine and sulphadoxine-pyrimethamine (SP), which remain in use as treatment for …
Pfcrt haplotypes and the evolutionary history of chloroquine-resistant Plasmodium falciparum
Mutations in the Pfcrt gene that change the resulting amino acids and form different
haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) …
haplotypes are common and correlate with the prevalence of chloroquine resistant (CQR) …
Evidence of Selective Sweeps in Genes Conferring Resistance to Chloroquine and Pyrimethamine in Plasmodium falciparum Isolates in India
T Mixson-Hayden, V Jain, AM McCollum… - Antimicrobial agents …, 2010 - Am Soc Microbiol
Treatment of Plasmodium falciparum is complicated by the emergence and spread of
parasite resistance to many of the first-line drugs used to treat malaria. Antimalarial drug …
parasite resistance to many of the first-line drugs used to treat malaria. Antimalarial drug …
Toll-like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control study
Background In malaria endemic areas, host genetics influence whether a Plasmodium
falciparum-infected child develops uncomplicated or severe malaria. TLR2 has been …
falciparum-infected child develops uncomplicated or severe malaria. TLR2 has been …
Toll-like receptor polymorphisms in malaria-endemic populations
JA Greene, AM Moormann, J Vulule, MJ Bockarie… - Malaria journal, 2009 - Springer
Background Toll-like receptors (TLR) and related downstream signaling pathways of innate
immunity have been implicated in the pathogenesis of Plasmodium falciparum malaria …
immunity have been implicated in the pathogenesis of Plasmodium falciparum malaria …
Population genetic analyses of Plasmodium falciparum chloroquine receptor transporter gene haplotypes reveal the evolutionary history of chloroquine-resistant …
Inferring the origin and dispersal of the chloroquine-resistant (CQR) malaria parasite,
Plasmodium falciparum, is of academic and public health importance. The Pfcrt gene of P …
Plasmodium falciparum, is of academic and public health importance. The Pfcrt gene of P …
Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea
M Sekihara, SI Tachibana, M Yamauchi, S Yatsushiro… - Malaria Journal, 2018 - Springer
Abstract Background Chloroquine treatment for Plasmodium falciparum has been
discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal …
discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal …
High prevalence of pfcrt-CVIET haplotype in isolates from asymptomatic and symptomatic patients in south-central Oromia, Ethiopia
Background As a result of extensive chloroquine resistance (CQR) in Plasmodium
falciparum in late 1990s, Ethiopia replaced CQ with sulphadoxine-pyrimethamine (SP) as …
falciparum in late 1990s, Ethiopia replaced CQ with sulphadoxine-pyrimethamine (SP) as …