Responses to highly aversive or potentially traumatic events are typically defined in terms of
binary outcomes, most commonly the presence or absence of post-traumatic stress disorder …

Cardiovascular events and emotional disorders share a common epidemiology, thus
suggesting fundamental pathways linking these different diseases. Growing evidence in the …

Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

Objective: Although mortality related to psychotropic medications has received much
attention in recent years, little is known about the relationship between risk of death and …

Unrecognized anxiety is a difficult clinical presentation in cardiology. Anxiety leads to
recurring emergency department visits and the need for numerous diagnostic evaluations to …

Depression in patients with cardiovascular disease is independently associated with
progression of heart disease, major adverse cardiac events, and mortality. A wide variety of …

Patients with major depression are at an increased risk for developing cardiovascular
disease, respond more poorly to treatment, and exhibit worse outcomes, including increased …

Many individuals with cardiovascular disease (CVD) experience depression that is
associated with poor health outcomes, which may be because of medication nonadherence …

Abstract Treatment-resistant depression refers to major depressive disorder, treatment of the
disorder, and failure to obtain an “acceptable” outcome. Regarding the disorder, the …

Background The impact of treatment resistant depression (TRD) on mortality is not
established. Methods Using Swedish national registers, 118,774 patients between 18–69 …