Background Per-and polyfluoroalkyl substances (PFAS) are chemicals that are resistant to
degradation and ubiquitous in our environments. PFAS may impact the developing …

While excessive production of reactive oxygen species (ROS) is a characteristic hallmark of
numerous diseases, clinical approaches that ameliorate oxidative stress have been …

Abstract Pharmacological phosphodiesterase 4D (PDE4D) inhibition shows therapeutic
potential to restore memory function in Alzheimer's disease (AD), but will likely evoke …

Sphingolipids (SLs) are bioactive lipids involved in various important physiological
functions. The SL pathway has been shown to be affected in several brain-related disorders …

Abstract Background Associations of arsenic (As) with the sum of 5-mC and 5-hmC levels
have been reported; however, As exposure-related differences of the separated 5-mC and 5 …

hydroxymethylcytosine (5hmC) is a methylation state linked with gene regulation, commonly
found in cells of the central nervous system. 5hmC is associated with demethylation of …

ABSTRACT DNA methylation, an epigenetic mark, has become a common outcome in
epidemiological studies with the aid of affordable and reliable technologies. Yet the most …

Recent studies have demonstrated that the dorsal raphe nucleus (DRN) is among the first
brain regions affected in Alzheimer's disease. Hence, in this study we conducted the first …

Cytosine modifications in DNA such as 5-methylcytosine (5mC) underlie a broad range of
developmental processes, maintain cellular lineage specification, and can define or stratify …

Abstract Simultaneous measurement of 5-methylcytosine (5-mC) and 5-
hydroxymethylcytosine (5-hmC) at the single-nucleotide level can be obtained by combining …