Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Inequalities in health outcomes impose substantial human and economic costs on all
societies—and the relation between early adversity and lifelong well-being presents a rich …

Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

Decades of research have revealed numerous risk factors for mental disorders beyond
genetics, but their consistency and magnitude remain uncertain. We conducted a “meta …

C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at
sites of infection or inflammation. CRP is produced as a homopentameric protein, termed …

Introduction: Adverse childhood experiences (ACE) such as sexual and physical abuse or
neglect are frequent in childhood and constitute a massive stressor with long-lasting …

Systemic chronic inflammation (SCI) is persistent, health-damaging, low-grade inflammation
that plays a major role in immunosenescence and in development and progression of many …

Abstract Purpose of Review We review recent developments on risk factors in
schizophrenia. Recent Findings The way we think about schizophrenia today is profoundly …

The study of the gut microbiome has increasingly revealed an important role in modulating
brain function and mental health. In this review, we underscore specific pathways and …