With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

Animal models of Parkinson's disease (PD) have proved highly effective in the discovery of
novel treatments for motor symptoms of PD and in the search for clues to the underlying …

Although mutations in mitochondrial-associated genes are linked to inflammation and
susceptibility to infection, their mechanistic contributions to immune outcomes remain ill …

Mitochondrial movements are tightly controlled to maintain energy homeostasis and prevent
oxidative stress. Miro is an outer mitochondrial membrane protein that anchors mitochondria …

Neurons are critically dependent on mitochondrial integrity based on specific morphological,
biochemical, and physiological features. They are characterized by high rates of metabolic …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …

Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of
Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes …

Abstract Parkinson's disease (PD), like many common age-related conditions, has been
recognized to have a substantial genetic component. Multiple lines of evidence suggest that …

Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …