There are limited proven therapeutic options for the prevention and treatment of COVID-19.
The role of vitamin and mineral supplementation or “immunonutrition” has previously been …

The human intestinal Caco-2 cell line has been extensively used over the last twenty years
as a model of the intestinal barrier. The parental cell line, originally obtained from a human …

Significance: Vitamin C, or ascorbic acid, has long been known to participate in several
important functions in the vascular bed in support of endothelial cells. These functions …

Our knowledge of the mechanisms and regulation of intestinal absorption of water-soluble
vitamins under normal physiological conditions, and of the factors/conditions that affect and …

Pregnancy is a unique immunological state in which a balance of immune tolerance and
suppression is needed to protect the fetus without compromising the mother. It has long …

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …

▪ Abstract Ascorbic acid and dehydroascorbic acid (DHAA, oxidized vitamin C) are dietary
sources of vitamin C in humans. Both nutrients are absorbed from the lumen of the intestine …

Vitamin C is accumulated in mammalian cells by two types of proteins: sodium-ascorbate co-
transporters (SVCTs) and hexose transporters (GLUTs); in particular, SVCTs actively import …

The literature on the content and stability of vitamin C (ascorbic acid, AA) in citrus juices in
relation to industrial practices is reviewed. The role of vitamin C from citrus juices in human …

The mechanisms allowing the cellular transport of ascorbic acid represent a primary aspect
for the understanding of the roles played by this vitamin in pathophysiology. Considerable …