Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
Redefining noradrenergic neuromodulation of behavior: impacts of a modular locus coeruleus architecture
DJ Chandler, P Jensen, JG McCall… - Journal of …, 2019 - Soc Neuroscience
The locus coeruleus (LC) is a seemingly singular and compact neuromodulatory nucleus
that is a prominent component of disparate theories of brain function due to its broad …
that is a prominent component of disparate theories of brain function due to its broad …
Neuromodulation in circuits of aversive emotional learning
E Likhtik, JP Johansen - Nature neuroscience, 2019 - nature.com
Emotional learning and memory are functionally and dysfunctionally regulated by the
neuromodulatory state of the brain. While the role of excitatory and inhibitory neural circuits …
neuromodulatory state of the brain. While the role of excitatory and inhibitory neural circuits …
Locus coeruleus norepinephrine drives stress-induced increases in basolateral amygdala firing and impairs extinction learning
Stress impairs extinction learning, and these deficits depend, in part, on stress-induced
norepinephrine (NE) release in the basolateral amygdala (BLA). For example, systemic or …
norepinephrine (NE) release in the basolateral amygdala (BLA). For example, systemic or …
Unrelenting fear under stress: neural circuits and mechanisms for the immediate extinction deficit
S Maren - Frontiers in Systems Neuroscience, 2022 - frontiersin.org
Therapeutic interventions for disorders of fear and anxiety rely on behavioral approaches
that reduce pathological fear memories. For example, learning that threat-predictive stimuli …
that reduce pathological fear memories. For example, learning that threat-predictive stimuli …
Parvalbumin-positive interneurons in the medial prefrontal cortex regulate stress-induced fear extinction impairments in male and female rats
AN Binette, J Liu, H Bayer, KL Crayton… - Journal of …, 2023 - Soc Neuroscience
Stress has profound effects on fear extinction, a form of learning that is essential to
behavioral therapies for trauma-related and stressor-related disorders. Recent work reveals …
behavioral therapies for trauma-related and stressor-related disorders. Recent work reveals …
[HTML][HTML] Trauma-informed care
H Forkey, M Szilagyi, ET Kelly, J Duffee - Pediatrics, 2021 - publications.aap.org
Heather Forkey, Moira Szilagyi, Erin T. Kelly, James Duffee, THE COUNCIL ON FOSTER
CARE, ADOPTION, AND KINSHIP CARE, COUNCIL ON COMMUNITY PEDIATRICS …
CARE, ADOPTION, AND KINSHIP CARE, COUNCIL ON COMMUNITY PEDIATRICS …
Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
The orbitofrontal cortex (OFC) is necessary for inferring value in tests of model-based
reasoning, including in sensory preconditioning. This involvement could be accounted for by …
reasoning, including in sensory preconditioning. This involvement could be accounted for by …
Adrenergic signaling in circadian control of immunity
S Leach, K Suzuki - Frontiers in immunology, 2020 - frontiersin.org
Circadian rhythms govern a multitude of physiologic processes, both on a cell-intrinsic level
and systemically, through the coordinated function of multi-organ biosystems. One such …
and systemically, through the coordinated function of multi-organ biosystems. One such …
Neural circuits for the adaptive regulation of fear and extinction memory
The regulation of fear memories is critical for adaptive behaviors and dysregulation of these
processes is implicated in trauma-and stress-related disorders. Treatments for these …
processes is implicated in trauma-and stress-related disorders. Treatments for these …