FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat
R Goold, M Flower, DH Moss, C Medway… - Human molecular …, 2019 - academic.oup.com
Huntington's disease (HD) is an inherited neurodegenerative disease caused by an
expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half …
expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half …
CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal
L Crozier, R Foy, BL Mouery, RH Whitaker… - The EMBO …, 2022 - embopress.org
CDK4/6 inhibitors arrest the cell cycle in G1‐phase. They are approved to treat breast
cancer and are also undergoing clinical trials against a range of other tumour types. To …
cancer and are also undergoing clinical trials against a range of other tumour types. To …
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
CDK4/6 inhibitors are remarkable anti-cancer drugs that can arrest tumor cells in G1 and
induce their senescence while causing only relatively mild toxicities in healthy tissues. How …
induce their senescence while causing only relatively mild toxicities in healthy tissues. How …
High-throughput silencing using the CRISPR-Cas9 system: a review of the benefits and challenges
M Wade - Journal of biomolecular screening, 2015 - journals.sagepub.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has
been seized upon with a fervor enjoyed previously by small interfering RNA (siRNA) and …
been seized upon with a fervor enjoyed previously by small interfering RNA (siRNA) and …
CtIP-mediated fork protection synergizes with BRCA1 to suppress genomic instability upon DNA replication stress
Protecting stalled DNA replication forks from degradation by promiscuous nucleases is
essential to prevent genomic instability, a major driving force of tumorigenesis. Several …
essential to prevent genomic instability, a major driving force of tumorigenesis. Several …
FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease
R Goold, J Hamilton, T Menneteau, M Flower… - Cell reports, 2021 - cell.com
CAG repeat expansion in the HTT gene drives Huntington's disease (HD) pathogenesis and
is modulated by DNA damage repair pathways. In this context, the interaction between …
is modulated by DNA damage repair pathways. In this context, the interaction between …
UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival
L Lee, AB Perez Oliva, E Martinez-Balsalobre… - Science …, 2021 - science.org
Ubiquitin-fold modifier 1 (UFM1) is involved in neural and erythroid development, yet its
biological roles in these processes are unknown. Here, we generated zebrafish models …
biological roles in these processes are unknown. Here, we generated zebrafish models …
Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability
Mono-ubiquitination of Fancd2 is essential for repairing DNA interstrand cross-links (ICLs),
but the underlying mechanisms are unclear. The Fan1 nuclease, also required for ICL …
but the underlying mechanisms are unclear. The Fan1 nuclease, also required for ICL …
Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling
S Strickson, CH Emmerich, ETH Goh… - Proceedings of the …, 2017 - National Acad Sciences
It is widely accepted that the essential role of TRAF6 in vivo is to generate the Lys63-linked
ubiquitin (K63-Ub) chains needed to activate the “master” protein kinase TAK1. Here, we …
ubiquitin (K63-Ub) chains needed to activate the “master” protein kinase TAK1. Here, we …
Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses
Homeodomain interacting protein kinase-2 (HIPK2) is a member of the HIPK family of stress-
responsive kinases that modulates cell growth, apoptosis, proliferation and development …
responsive kinases that modulates cell growth, apoptosis, proliferation and development …