Currently, the emergence and ongoing dissemination of antimicrobial resistance among
bacteria are critical health and economic issue, leading to increased rates of morbidity and …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Gram-negative bacteria depend on their cell membranes for survival and environmental
adaptation. They contain two membranes, one of which is the outer membrane (OM), which …

The cell envelope is essential for survival and adaptation of bacteria. Bacterial membrane
proteins include the major porins that mediate the influx of nutrients and several classes of …

Catalytic oxidative functionalization of alkynes has emerged as an effective method in
synthetic chemistry in recent decades. However, enantioselective transformations via metal …

The spread of carbapenem-and polymyxin-resistant Enterobacteriaceae poses a significant
threat to public health, challenging clinicians worldwide with limited therapeutic options. This …

Due to the extensive application of antibiotics in medical and farming practices, the
continued diversification and development of antimicrobial resistance (AMR) has attracted …

The outer membrane of Gram-negative bacteria plays a critical role in protecting the cell
against external stressors, including antibiotics, and therefore is a prime target for …

Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria serve as transporters
for the delivery of cargo such as virulence and antibiotic resistance factors. OMVs play a key …

Salmonella is an important pathogen causing food poisoning. Food safety and health are
the themes of today′ s society. As a class of food-borne pathogens, Salmonella enteritidis …