Lactate in the brain: from metabolic end-product to signalling molecule

PJ Magistretti, I Allaman - Nature reviews neuroscience, 2018 - nature.com
Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

[HTML][HTML] Expanding the function of oligodendrocytes to brain energy metabolism

KA Nave, E Asadollahi, A Sasmita - Current Opinion in Neurobiology, 2023 - Elsevier
Oligodendrocytes are best known for wrapping myelin, a unique specialization that enables
energy-efficient and fast axonal impulse propagation in white matter tracts and fibers of the …

Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

E Asadollahi, A Trevisiol, AS Saab, ZJ Looser… - Nature …, 2024 - nature.com
Brain function requires a constant supply of glucose. However, the brain has no known
energy stores, except for glycogen granules in astrocytes. In the present study, we report that …

Ensheathment and myelination of axons: evolution of glial functions

KA Nave, HB Werner - Annual Review of Neuroscience, 2021 - annualreviews.org
Myelination of axons provides the structural basis for rapid saltatory impulse propagation
along vertebrate fiber tracts, a well-established neurophysiological concept. However …

Metabolic interaction between Schwann cells and axons under physiological and disease conditions

F Bouçanova, R Chrast - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Recent research into axon-glial interactions in the nervous system has made a compelling
case that glial cells have a relevant role in the metabolic support of axons, and that, in the …

Axonal ensheathment in the nervous system of lamprey: implications for the evolution of myelinating glia

MT Weil, S Heibeck, M Töpperwien… - Journal of …, 2018 - Soc Neuroscience
In the nervous system, myelination of axons enables rapid impulse conduction and is a
specialized function of glial cells. Myelinating glia are the last cell type to emerge in the …

Myelin lipids as nervous system energy reserves

E Asadollahi, A Trevisiol, AS Saab, ZJ Looser, P Dibaj… - bioRxiv, 2022 - biorxiv.org
Neuronal functions and impulse propagation depend on the continuous supply of glucose,.
Surprisingly, the mammalian brain has no obvious energy stores, except for astroglial …

Myelin lipid metabolism can provide energy for starved axons

E Asadollahi, KA Nave - Nature Neuroscience, 2024 - nature.com
We reveal that lipid turnover in the myelin sheath generates a fatty acid pool in
oligodendrocytes that can contribute to the energy balance of white matter tracts. We also …

The glial UDP-glycosyltransferase Ugt35b regulates longevity by maintaining lipid homeostasis in Drosophila

L Sheng, J Gao, Q Wei, Y Gong, ZX Xu - Cell Reports, 2025 - cell.com
Lipid droplets (LDs) are dynamic organelles essential for lipid storage and organismal
survival. Studies have highlighted the importance of glial function in brain LD formation …

Arsenic Exposure Induces Neural Cells Senescence and Abnormal Lipid Droplet Accumulation Leading to Social Memory Impairment in Mice

B Zhang, J Chen, J Wang, X Pan - Environmental Pollution, 2025 - Elsevier
The long-term harmful effects of arsenic exposure remain one of the important public health
issues. The effects of arsenic exposure on the central nervous system, particularly …